Isoform specificity of progesterone receptor antibodies
Abstract
Progesterone receptors (PR) are prognostic and predictive biomarkers in hormone‐dependent cancers. Two main PR isoforms have been described, PRB and PRA, that differ only in that PRB has 164 extra N‐terminal amino acids. It has been reported that several antibodies empirically exclusively recognize PRA in formalin‐fixed paraffin‐embedded (FFPE) tissues. To confirm these findings, we used human breast cancer xenograft models, T47D‐YA and ‐YB...
Paper Details
Title
Isoform specificity of progesterone receptor antibodies
Published Date
Oct 1, 2017
Journal
Volume
3
Issue
4
Pages
227 - 233
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