Victoria T. Fabris
Instituto de Biología y Medicina Experimental
CancerEndocrinologyChromosomal translocationMolecular biologyReceptorIn vivoMammary tumorMedroxyprogesterone acetateEstrogenMammary glandCancer researchBreast cancerKaryotypeCell growthHormoneMedicineEstrogen receptorBiologyCancer cellProgesterone receptor
28Publications
10H-index
404Citations
Publications 28
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#1Andrés ElíaH-Index: 2
#2Silvia VanzulliH-Index: 18
Last. Claudia LanariH-Index: 24
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#1Daniela BispoH-Index: 1
#2Victoria T. FabrisH-Index: 10
Last. Ana M. GilH-Index: 44
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#2Claudia Lanari (Instituto de Biología y Medicina Experimental)H-Index: 24
Last. Victoria T. FabrisH-Index: 10
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#1Melina Bilinski (Instituto de Biología y Medicina Experimental)
#2Claudia Lanari (Instituto de Biología y Medicina Experimental)H-Index: 24
Last. Victoria T. Fabris (Instituto de Biología y Medicina Experimental)H-Index: 10
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Centrosome amplification leads to aberrant mitosis, giving rise to aneuploidy and it has been associated with poor prognosis in human cancers. The aim of this study was to evaluate the relationship between polyploidy, centrosome abnormalities and response to endocrine treatment in progestin-induced mouse mammary carcinomas. We found cells with three or more centrosomes in the polyploid tumors. The endocrine unresponsive tumors showed a higher average number of centrosomes per cell than the respo...
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#1Caroline A. Lamb (Instituto de Biología y Medicina Experimental)H-Index: 11
#2Victoria T. Fabris (Instituto de Biología y Medicina Experimental)H-Index: 10
Last. Claudia Lanari (Instituto de Biología y Medicina Experimental)H-Index: 24
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Abstract Progesterone is a pregnancy-related hormone that prepares the endometrium for the implantation of the fertilized zygote and suppresses myometrial contractility for the maintenance of pregnancy. At high concentrations it acts as a natural immunosuppressant avoiding the rejection of a half allogeneic foetus. It is the precursor of many other related steroid hormones, but what’s its role in the human breast? In this chapter we will discuss some aspects related with progesterone and its rol...
1 CitationsSource
#1Marina Ayre (Instituto de Biología y Medicina Experimental)
#2Melina Bilinski (Instituto de Biología y Medicina Experimental)
Last. Victoria T. Fabris (Instituto de Biología y Medicina Experimental)H-Index: 10
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Deregulation of cyclin A expression has been associated with prognosis and tamoxifen responsiveness in breast cancer. We have previously reported an overexpression of cyclin A in two antiprogestin-resistant tumors derived from a hormone-dependent mammary carcinoma induced by medroxyprogesterone acetate (MPA). MPA-induced tumors show high levels of estrogen (ER) and progesterone receptors (PR) and transit through different stages of hormone dependency. Taking into account that antiprogestin-sensi...
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#1Caroline A. Lamb (Instituto de Biología y Medicina Experimental)H-Index: 11
#2Victoria T. Fabris (Instituto de Biología y Medicina Experimental)H-Index: 10
Last. Claudia Lanari (Instituto de Biología y Medicina Experimental)H-Index: 24
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Fil: Lamb, Caroline Ana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Biologia y Medicina Experimental. Fundacion de Instituto de Biologia y Medicina Experimental. Instituto de Biologia y Medicina Experimental; Argentina
11 CitationsSource
#1M LiguoriH-Index: 1
#2Claudia LanariH-Index: 24
Last. Alfredo A. MolinoloH-Index: 59
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Seventy percent of breast cancers express estrogen (ER) and progesterone receptors (PR) and respond to antiestrogen therapies. Emerging evidence from experimental studies and human epidemiology, points to a relevant role for progestins in breast carcinogenesis and cancer growth. Others and we have proposed that there is a role for antiprogestins in the therapeutic armamentarium, but the challenge remains to identify which patients would benefit from targeting the PR in addition to ER. Preclinica...
1 CitationsSource
#1Victoria T. Fabris (CONICET: National Scientific and Technical Research Council)H-Index: 10
#2María Florencia Abascal (Instituto de Biología y Medicina Experimental)H-Index: 4
Last. Claudia Lanari (CONICET: National Scientific and Technical Research Council)H-Index: 24
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Progesterone receptors (PR) are prognostic and predictive biomarkers in hormone-dependent cancers. Two main PR isoforms have been described, PRB and PRA, that differ only in that PRB has 164 extra N-terminal amino acids. It has been reported that several antibodies empirically exclusively recognize PRA in formalin-fixed paraffin-embedded tissues (FFPE). To confirm these findings, we used human breast cancer xenograft models, T47D-YA and -YB cells expressing PRA or PRB respectively, MDA-MB-231 ce...
8 CitationsSource
#1Melina Bilinski (Instituto de Biología y Medicina Experimental)
#2Claudia Lanari (Instituto de Biología y Medicina Experimental)H-Index: 24
Last. Victoria T. Fabris (Instituto de Biología y Medicina Experimental)H-Index: 10
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Most of human breast cancers are aneuploid because of chromosome missegregation occurring during mitosis. Deregulation in the control of cell cycle progression is frequently found in mammary carcinomas and is associated with mitotic spindle checkpoint defects and aneuploidy. The Laboratory of Hormonal Carcinogenesis has developed an experimental model of mammary carcinomas by the administration of medroxyprogesterone acetate (MPA) to BALB/c mice. These tumors are metastatic luminal ductal carcin...
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