Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

Science56.90
Volume: 358, Issue: 6359, Pages: 85 - 90
Published: Oct 6, 2017
Abstract
The development of an effective AIDS vaccine has been challenging because of viral genetic diversity and the difficulty of generating broadly neutralizing antibodies (bnAbs). We engineered trispecific antibodies (Abs) that allow a single molecule to interact with three independent HIV-1 envelope determinants: the CD4 binding site, the membrane-proximal external region (MPER), and the V1V2 glycan site. Trispecific Abs exhibited higher potency and...
Paper Details
Title
Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques
Published Date
Oct 6, 2017
Journal
Volume
358
Issue
6359
Pages
85 - 90
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