Original paper
Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis
Volume: 127, Issue: 10, Pages: 3675 - 3688
Published: Sep 4, 2017
Abstract
TGF-β1 signaling is a critical driver of collagen accumulation and fibrotic disease but also a vital suppressor of inflammation and epithelial cell proliferation. The nature of this multifunctional cytokine has limited the development of global TGF-β1 signaling inhibitors as therapeutic agents. We conducted phenotypic screens for small molecules that inhibit TGF-β1–induced epithelial-mesenchymal transition without immediate TGF-β1 receptor (TβR)...
Paper Details
Title
Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis
Published Date
Sep 4, 2017
Volume
127
Issue
10
Pages
3675 - 3688