CLIP-seq analysis of multi-mapped reads discovers novel functional RNA regulatory sites in the human transcriptome

Volume: 45, Issue: 16, Pages: 9260 - 9271
Published: Aug 9, 2017
Abstract
Crosslinking or RNA immunoprecipitation followed by sequencing (CLIP-seq or RIP-seq) allows transcriptome-wide discovery of RNA regulatory sites. As CLIP-seq/RIP-seq reads are short, existing computational tools focus on uniquely mapped reads, while reads mapped to multiple loci are discarded. We present CLAM (CLIP-seq Analysis of Multi-mapped reads). CLAM uses an expectation–maximization algorithm to assign multi-mapped reads and calls peaks...
Paper Details
Title
CLIP-seq analysis of multi-mapped reads discovers novel functional RNA regulatory sites in the human transcriptome
Published Date
Aug 9, 2017
Volume
45
Issue
16
Pages
9260 - 9271
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