Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells.

Science56.90
Volume: 357, Issue: 6353, Pages: 806 - 810
Published: Aug 25, 2017
Abstract
The small intestine contains CD4 + CD8αα + null double-positive intraepithelial lymphocytes (DP IELs), which originate from intestinal CD4 + null T cells through down-regulation of the transcription factor Thpok and have regulatory functions. DP IELs are absent in germ-free mice, which suggests that their differentiation depends on microbial factors. We found that DP IEL numbers in mice varied in different vivaria, correlating with the presence...
Paper Details
Title
Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells.
DOI
Published Date
Aug 25, 2017
Journal
Volume
357
Issue
6353
Pages
806 - 810
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