Abstract 4399: MUC13 induced NFκB activation regulates metabolic reprograming by promoting its crosstalk with GLUT-1 receptor

Objective: Pancreatic cancer (PanCa) is the fourth most common cause of cancer-related deaths in the US. MUC13, mucin is aberrantly expressed in PanCa and promotes tumor growth and progression. Herein, we investigate the fundamental role of MUC13 in glucose metabolism and delineate the molecular interplay of various molecules governing MUC13 mediated metabolic reprograming that may be involved in pancreatic tumor maintenance. Methods: MUC13...