Sheema Khan
University of Tennessee Health Science Center
CancerInternal medicineOncologymicroRNAChemistryApoptosisImmunologyOrmeloxifeneChemotherapyPancaMetastasisDrug deliveryProstate cancerPancreatic cancerGemcitabineCell cycleCancer researchCell growthMedicineBiologyCell biologyCancer cell
79Publications
23H-index
1,681Citations
Publications 70
Newest
#1Mohammed Sikander (UTHSC: University of Tennessee Health Science Center)H-Index: 7
#2Shabnam Malik (UTHSC: University of Tennessee Health Science Center)H-Index: 8
Last. Subhash C. ChauhanH-Index: 49
view all 11 authors...
Pancreatic cancer (PanCa) is one of the leading causes of death from cancer in the United States. The current standard treatment for pancreatic cancer is gemcitabine, but its success is poor due to the emergence of drug resistance. Natural products have been widely investigated as potential candidates in cancer therapies, and cucurbitacin D (Cuc D) has shown excellent anticancer properties in various models. However, there is no report on the therapeutic effect of Cuc D in PanCa. In the present ...
4 CitationsSource
#1Kamalika SamantaH-Index: 2
#2Sheema Khan (UTHSC: University of Tennessee Health Science Center)H-Index: 23
Last. Subhash Chandra Chauhan (UTHSC: University of Tennessee Health Science Center)H-Index: 1
view all 8 authors...
Background-Pancreatic cancer (PanCa) is the third deadliest cancer in United States with a poor survival rate. Despite extensive research efforts, there is no substantial progress in cancer therapeutics due to barrier against intracellular drug delivery. Our group has previously identified that microRNA-145 (miR-145) is downregulated in PanCa, the restoration of which inhibits tumor growth and enhances gemcitabine sensitivity. However, lack of an effective tumor-specific delivery system remains ...
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#1Nirnoy Dan (UTHSC: University of Tennessee Health Science Center)H-Index: 6
#2Sheema Khan (UTHSC: University of Tennessee Health Science Center)H-Index: 23
Last. Subhash C. Chauhan (UTHSC: University of Tennessee Health Science Center)H-Index: 49
view all 9 authors...
Background: Although, surgical resection and chemotherapy are the gold standard for treating pancreatic cancer (PanCa), poor patient survival remains the problem. Despite being one of the most common oncogenes in human cancer, to date, no success has been achieved to inhibit KRAS. Targeting KRAS has been shown to synergize anti-cancer activity of gemcitabine in pancreatic cancer. Herein, we have developed a supermagnetic iron oxide (SP) nanoparticles for the sustained delivery of KRAS siRNA to t...
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#1Sheema Khan (UTHSC: University of Tennessee Health Science Center)H-Index: 23
#2Saini Setua (UTHSC: University of Tennessee Health Science Center)H-Index: 7
Last. Subhash C. Chauhan (UTHSC: University of Tennessee Health Science Center)H-Index: 49
view all 14 authors...
Abstract Pancreatic cancer is a complex disease accounting for fibrotic tumors and an aggressive phenotype. Gemcitabine (GEM) is used as a standard therapy, which develops chemoresistance leading to poor patient outcome. We have recently developed a superparamagnetic iron oxide nanoparticle (SPION) formulation of curcumin (SP-CUR), which is a nontoxic, bioactive anti-inflammatory/anti-cancer agent for its enhanced delivery in tumors. In this study, we demonstrate that SP-CUR effectively delivers...
24 CitationsSource
#1Saini SetuaH-Index: 7
#2Sheema KhanH-Index: 23
Last. Subhash C. ChauhanH-Index: 49
view all 8 authors...
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#1Pallabita Chowdhury (UTHSC: University of Tennessee Health Science Center)H-Index: 12
#2Prashanth K.B. Nagesh (UTHSC: University of Tennessee Health Science Center)H-Index: 10
Last. Murali M. Yallapu (UTHSC: University of Tennessee Health Science Center)H-Index: 34
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Abstract Paclitaxel (PTX) is a gold standard chemotherapeutic agent for breast, ovarian, pancreatic and non-small cell lung carcinoma. However, in clinical use PTX can have adverse side effects or inadequate pharmacodynamic parameters, limiting its use. Nanotechnology is often employed to reduce the therapeutic dosage required for effective therapy, while also minimizing the systemic side effects of chemotherapy drugs. However, there is no nanoformulation of paclitaxel with chemosensitization mo...
29 CitationsSource
Transmission intensity of a thin tissue sample produce intensity distribution that is proportional to the refractive index pattern in the thin slice, in turn reflects mass density pattern, and using the intensity pattern, fractal dimension can be calculated. In this paper, we report fractal dimension analyses of MUC13 stained pancreatic cancer tissues. Pancreatic cancer is deadliest due to its physical orientation, and no prominent chemical change till the late stages of cancer. The presence of ...
#1Prashanth K.B. Nagesh (UTHSC: University of Tennessee Health Science Center)H-Index: 10
#2Pallabita Chowdhury (UTHSC: University of Tennessee Health Science Center)H-Index: 12
Last. Murali M. Yallapu (UTHSC: University of Tennessee Health Science Center)H-Index: 34
view all 10 authors...
: The therapeutic application of microRNA(s) in the field of cancer has generated significant attention in research. Previous studies have shown that miR-205 negatively regulates prostate cancer cell proliferation, metastasis, and drug resistance. However, the delivery of miR-205 is an unmet clinical need. Thus, the development of a viable nanoparticle platform to deliver miR-205 is highly sought. A novel magnetic nanoparticle (MNP)-based nanoplatform composed of an iron oxide core with poly(eth...
16 CitationsSource
#1Zachary E. Stiles (UTHSC: University of Tennessee Health Science Center)H-Index: 7
#2Sheema Khan (UTHSC: University of Tennessee Health Science Center)H-Index: 23
Last. Subhash C. Chauhan (UTHSC: University of Tennessee Health Science Center)H-Index: 49
view all 6 authors...
Abstract Background Intraductal papillary mucinous neoplasms (IPMN) are currently managed based on imaging characteristics and cyst fluid sampling. This study was designed to determine if MUC13, a glycoprotein aberrantly overexpressed in pancreatic adenocarcinoma, might aid in distinguishing high-risk lesions (high grade dysplasia/invasive disease) from low-grade lesions. Methods MUC13 immunohistochemical staining was performed on surgically resected formalin-fixed tissue specimens from 49 IPMNs...
3 CitationsSource
#1Sheema KhanH-Index: 23
#2Pratik BanerjeeH-Index: 16
Last. Subhash C. ChauhanH-Index: 49
view all 8 authors...
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