Abstract LB-122: Tumor heterogeneity in castration resistant neuroendocrine prostate cancer from whole exome sequencing of circulating tumor DNA

Background: We recently identified mechanisms underlying the clonal evolution of castration resistant prostate adenocarcinoma (CRPC-Adeno) to a neuroendocrine resistance phenotype (Beltran et al, Nature Med 2016). In the current study, we aimed to develop a non-invasive approach to identify patients that are developing neuroendocrine prostate cancer (NEPC). Methods: We performed whole exome sequencing (WES) of matched circulating tumor DNA...