The Dkk3 gene encodes a vital intracellular regulator of cell proliferation
Abstract
Members of the Dickkopf (Dkk) family of Wnt antagonists interrupt Wnt-induced receptor assembly and participate in axial patterning and cell fate determination. One family member, DKK3, does not block Wnt receptor activation. Loss of Dkk3 expression in cancer is associated with hyperproliferation and dysregulated ß-catenin signaling, and ectopic expression of Dkk3 halts cancer growth. The molecular events mediating the DKK3-dependent arrest of...
Paper Details
Title
The Dkk3 gene encodes a vital intracellular regulator of cell proliferation
Published Date
Jul 24, 2017
Journal
Volume
12
Issue
7
Pages
e0181724 - e0181724
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