Cytoreductive debulking surgery among patients with neuroendocrine liver metastasis: a multi-institutional analysis

Published on Apr 1, 2017in Hpb3.401
· DOI :10.1016/J.HPB.2017.08.039
Aslam Ejaz34
Estimated H-index: 34
(Johns Hopkins University),
Bradley N. Reames19
Estimated H-index: 19
(Johns Hopkins University)
+ 7 AuthorsTimothy M. Pawlik118
Estimated H-index: 118
(OSU: Ohio State University)
Abstract Background Management of neuroendocrine liver metastasis (NELM) in the setting of unresectable disease is poorly defined and the role of debulking remains controversial. The objective of the current study was to define outcomes following non-curative intent liver-directed therapy (debulking) among patients with NELM. Methods 612 patients were identified who underwent liver-directed therapy of NELM from a multi-institutional database. Outcomes were stratified according to curative (R0/R1) versus non-curative ≥ 80% debulking (R2). Results 179 (29.2%) patients had an R2/debulking procedure. Patients undergoing debulking more commonly had more aggressive high-grade tumors (R0/R1: 12.8% vs. R2: 35.0%; P  Conclusion Debulking operations for NELM provided reasonable long-term survival. Hepatic debulking for patients with NELM is a reasonable therapeutic option for patients with grossly unresectable disease that may provide a survival benefit.
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