The effect of cryotherapy on total antioxidative capacity in patients with active seropositive rheumatoid arthritis

Patients with rheumatoid arthritis (RA) have increased oxidative stress, decreased antioxidant levels, and impaired antioxidant capacity. Cold treatments are used to relieve joint inflammation and pain. Therefore, we measured the effect of cold treatments on the antioxidative capacity of RA patients with active disease. Sixty patients were randomized to (1) whole body cryotherapy at −110 °C, (2) whole body cryotherapy at −60 °C, or (3) local...