Genomic Signature of the Natural Oncolytic Herpes Simplex Virus HF10 and Its Therapeutic Role in Preclinical and Clinical Trials

Oncolytic viruses are opening new possibilities in cancer therapy with their unique mechanism of selective replication within tumor cells and triggering of anti-tumor immune responses. HF10 is an oncolytic herpes simplex virus-1 (HSV-1) with a unique genomic structure that has non-engineered deletions and insertions accompanied by frame shift mutations, in contrast to the majority of engineered oncolytic viruses. At the genetic level, HF10...