Negri bodies are viral factories with properties of liquid organelles

Volume: 8, Issue: 1
Published: Jul 5, 2017
Abstract
Replication of Mononegavirales occurs in viral factories which form inclusions in the host-cell cytoplasm. For rabies virus, those inclusions are called Negri bodies (NBs). We report that NBs have characteristics similar to those of liquid organelles: they are spherical, they fuse to form larger structures, and they disappear upon hypotonic shock. Their liquid phase is confirmed by FRAP experiments. Live-cell imaging indicates that viral...
Paper Details
Title
Negri bodies are viral factories with properties of liquid organelles
Published Date
Jul 5, 2017
Volume
8
Issue
1
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