Hypocretin (orexin) is critical in sustaining theta/gamma-rich waking behaviors that drive sleep need

Abstract
Hcrt gene inactivation in mice leads to behavioral state instability, abnormal transitions to paradoxical sleep, and cataplexy, hallmarks of narcolepsy. Sleep homeostasis is, however, considered unimpaired in patients and narcoleptic mice. We find that whereas Hcrtko/ko mice respond to 6-h sleep deprivation (SD) with a slow-wave sleep (SWS) EEG δ (1.0 to 4.0 Hz) power rebound like WT littermates, spontaneous waking fails to induce a δ power...
Paper Details
Title
Hypocretin (orexin) is critical in sustaining theta/gamma-rich waking behaviors that drive sleep need
Published Date
Jun 19, 2017
Volume
114
Issue
27
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