PHOX2B reliably distinguishes neuroblastoma among small round blue cell tumours

Aims Neuroblastoma shows considerable histological overlap with other small round blue cell tumours. PHOX 2B, a transcription factor that is essential for autonomic nervous system development, has been reported as an immunohistochemical marker for neuroblastoma. The aim of this study was to validate the specificity and diagnostic utility of PHOX 2B for peripheral neuroblastic tumours. Methods and results We evaluated 240 cases (133 in...