AIMS This study investigated the relationship between the differentiation of tumour cells into crypts, which is determined by cell differentiation into Paneth and neuroendocrine cells, and tumour infiltration in gastric dysplasia. METHODS AND RESULTS The lesions were endoscopically biopsied low-grade dysplasia (LGD), endoscopically resected high-grade dysplasia (HGD), or cancer with submucosal invasion. LGD (n = 32) displayed crypt differentiation across the entire width of the tumour in all cas...
Last. Irene Oi-Lin Ng(HKU: University of Hong Kong)H-Index: 110
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Background null Lymphoepithelioma-like carcinomas (LELCs) are uncommon epithelial cancers characteristically showing two distinct components consisting of malignant epithelial cells and prominent dense lymphoid infiltrate. Hepatic LELCs consist of two types, the lymphoepithelioma-like hepatocellular carcinoma and lymphoepithelioma-like cholangiocarcinoma (LEL-CCA), with the latter being strongly associated with Epstein Barr virus (EBV). null Methods null We present a series of three cases of int...
Last. Ivy John(University of Pittsburgh)H-Index: 4
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Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is a clinically and histologically distinct variant of inflammatory myofibroblastic tumor that is characterized by an aggressive clinical course and dismal prognosis (1). Histologically, EIMS is composed of sheets of rounded or epithelioid cells with vesicular nuclei, large nucleoli, and eosinophilic to amphophilic cytoplasm, that is often set in a myxoid stroma rich in inflammatory cells. A minor spindle cell component is usually present. ...
Last. Emad A. Rakha(University of Nottingham)H-Index: 75
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Background null Although evaluation of nuclear morphology plays a crucial role in the diagnosis and categorisation of breast lesions, the criteria used to assess nuclear atypia rely on the subjective evaluation of several features that may result in inter- and intra-observer variation. This study aims to refine the definitions of cytonuclear features in various breast lesions. null Methods null ImageJ was used to assess the nuclear morphological features including nuclear diameter, axis length, ...
A 76-year-old women presented with abdominal pain. Diagnostic investigations suggested peritoneal carcinomatosis. Histological examination of laparoscopic biopsies showed large epithelioid cells forming sheets intermingled with some lymphocytes. There was no clearly distinguishable stroma. Immunohistochemistry showed diffuse and strong expression of cytokeratin AE1/AE3, synaptophysin and chromogranin-A.
#2Michael G. Drage(URMC: University of Rochester Medical Center)
Last. Raul S. Gonzalez(URMC: University of Rochester Medical Center)H-Index: 19
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INTRODUCTION Management of anal dysplasia relies on the accurate diagnosis of anal biopsy specimens. As institutions move toward subspecialty signout (SSSO), decisions must be made regarding whether to assign anal biopsies to the gastrointestinal (GI) or gynaecologic (GYN) pathology service. MATERIALS AND METHODS We identified 200 archival tissue biopsies of anal mucosa and circulated them among three GI pathologists and three GYN pathologists. Each pathologist separately scored each biopsy as n...
#2Gagan Prakash(HBNI: Homi Bhabha National Institute)H-Index: 5
Last. M. Pal(HBNI: Homi Bhabha National Institute)H-Index: 4
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AIMS The recent changes in the American Joint Commission on Cancer-8th edition (AJCC-8E) pT2 and pT3 tumor definitions for penile cancer need robust validation studies. A recent study redefined and modified the pT2 and pT3 stages incorporating the histopathological variables (tumor grade, lymphovascular invasion, perineural invasion) similar to that used in the current AJCC-8E pT1 stage tumor subclassification. In this study, we validate and compare this proposed staging with the AJCC staging sy...
Last. Philip D. Dunne('QUB': Queen's University Belfast)H-Index: 19
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AIMS Tumour budding is an established prognostic feature in multiple cancers but is not routinely assessed in pathology practice. Efforts to standardise and automate assessment have shifted from haematoxylin and eosin (H&E)-stained images towards cytokeratin immunohistochemistry. In this study, we compare manual H&E and cytokeratin assessment methods with a semi-automated approach built within QuPath open-source software. METHODS AND RESULTS Budding was assessed in cores from the advancing tumou...
AIMS Gastrointestinal stromal tumors (GISTs) typically show uniform nuclear morphology, with spindle cell, epithelioid, or mixed histology. Risk of progression in GIST is estimated based on anatomic site, tumor size, and mitotic index. Pleomorphic GISTs are rare and have not been systemically investigated. We evaluated the prognostic significance of pleomorphism in GIST. METHODS AND RESULTS In total, 108 of 2517 (4.3%) GISTs reviewed between 2000-2021 were reported to show pleomorphism. Seventee...
Superficial angiomyxomas are cutaneous mesenchymal tumors that typically present clinically as slow-growing, solitary, asymptomatic nodules that can occur at any age. Histopathologically, these dermal and subcutaneous tumors are characterized by abundant myxoid stroma, numerous thin-walled and often arborizing blood vessels, and spindled to stellate fibroblast-like cells. While usually sporadic, superficial angiomyxomas can occasionally be associated with Carney complex (CNC), an autosomal domin...