miR-1224 inhibits cell proliferation in acute liver failure by targeting the antiapoptotic gene Nfib

Acute liver failure (ALF) represents a life-threatening condition associated with high morbidity and mortality. In ALF, liver cell death normally induces compensatory cell proliferation to restore liver mass and avoid loss of organ function.1,2 While the balance of liver regeneration and hepatocyte death plays a critical role in the outcome of ALF,3,4 the underlying regulatory mechanisms linking cell death with compensatory proliferation are...