Downregulation and upregulation

Cell

Biology

Gene

Gene silencing

microRNA

Apoptosis

Immunology

Programmed cell death

Cell growth

Cell biology

Cancer research

Genetics

Journal of Hepatology

Acute liver failure (ALF) represents a life-threatening condition associated with high morbidity and mortality. In ALF, liver cell death normally induces compensatory cell proliferation to restore liver mass and avoid loss of organ function.1,2 While the balance of liver regeneration and hepatocyte death plays a critical role in the outcome of ALF,3,4 the underlying regulatory mechanisms linking cell death with compensatory proliferation are still only poorly understood.

miR-1224 inhibits cell proliferation in acute liver failure by targeting the antiapoptotic gene Nfib