Identification of CD146 as a novel molecular actor involved in systemic sclerosis

Systemic sclerosis (SSc) is a fibrosing autoimmune disorder characterized by vascular damage, excessive fibrosis in the skin and internal organs, and immune dysfunction.1Gabrielli A. Avvedimento E.V. Krieg T. Scleroderma.N Engl J Med. 2009; 360: 1989-2003Crossref PubMed Scopus (1144) Google Scholar Pulmonary fibrosis and pulmonary arterial hypertension are the most serious complications and currently constitute the major causes of death. The...