Original paper
Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy
Volume: 9, Issue: 1, Pages: 47 - 62
Published: Jun 8, 2017
Abstract
Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary complex-type oligosaccharide attached to Asn297 of the Fc is essential for antibody effector functions, fucose and outer-arm sugars attached to the core heptasaccharide that generate structural heterogeneity (glycoforms) exhibit unique biological activities. Hence, efficient and quantitative glycan...
Paper Details
Title
Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy
Published Date
Jun 8, 2017
Volume
9
Issue
1
Pages
47 - 62
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Notes
History