Mendelian randomization in cardiometabolic disease: challenges in evaluating causality

Mendelian randomization (MR) is an increasingly common tool that involves the use of genetic variants to evaluate causal relationships between exposures and outcomes. In this Review, Holmes et al. describe some of the scenarios in which findings from MR analyses can be challenging to evaluate, using examples from studies on cardiometabolic diseases. Mendelian randomization (MR) is a burgeoning field that involves the use of genetic variants to...