Nature Reviews Cardiology
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32.43
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Researchers have developed a cardiac patch that is injectable, maintains its shape and electrically integrates with the myocardium, thereby improving functional recovery after myocardial infarction.
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A form of adenine base editing has been used in mouse embryos to correct a genetic variant associated with hypertrophic cardiomyopathy. This approach is potentially safer than other forms of germline gene editing, which carry a risk of off-target editing and the introduction of indels.
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A new study shows that adult mouse cardiomyocytes can be reversibly dedifferentiated into fetal-like cardiomyocytes by forcing the transient expression of four pluripotency factors, which enables cardiomyocytes to re-enter the cell cycle and divide, thereby conferring regenerative capacity to the adult heart.
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A new study shows that anti-IL-1β treatment and NLRP3 inflammasome inhibition ameliorate vascular inflammation and atherosclerosis progression by two mechanisms: a reduction in blood inflammatory leukocyte supply and a decrease in inflammatory leukocyte uptake into atherosclerotic lesions.
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#1Mitchell Sarkies (Curtin University)H-Index: 10
#2Laney K. JonesH-Index: 7
Last. Gerald F. Watts (UWA: University of Western Australia)H-Index: 116
view all 4 authors...
Clinical practice guidelines provide evidence-informed recommendations to improve the delivery of high-quality health care. Despite their ubiquity, the translation of clinical guidelines into routine clinical practice remains suboptimal. We propose the use of implementation science methods in the development of clinical practice guidelines to improve uptake.
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Two new studies show that titin haploinsufficiency and the toxicity of aggregated truncated titin protein together contribute to the pathogenesis of dilated cardiomyopathy caused by truncating variants in the gene encoding titin.
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#1Petra Kleinbongard (University of Duisburg-Essen)H-Index: 44
#2Gerd Heusch (University of Duisburg-Essen)H-Index: 119
Mechanical stress from haemodynamic perturbations or interventional manipulation of epicardial coronary atherosclerotic plaques with inflammatory destabilization can release particulate debris, thrombotic material and soluble substances into the coronary circulation. The physical material obstructs the coronary microcirculation, whereas the soluble substances induce endothelial dysfunction and facilitate vasoconstriction. Coronary microvascular obstruction and dysfunction result in patchy microi...
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#1Wei Chen (Brigham and Women's Hospital)H-Index: 4
#2Maaike Schilperoort (Columbia University)H-Index: 1
Last. Wei Tao (Brigham and Women's Hospital)H-Index: 52
view all 6 authors...
Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis and contribute to the development of novel diagnostic and therapeutic strategies to further reduce the risk of cardiovascular disease. Macrophages have key roles in atherosclerosis progression and, therefore, macrophage-associated pathological processes are important targets for both diagnostic imaging and novel therapies for atherosclerosis. In this Review, we highlight efforts in the past two decades to de...
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Cardiac sex-specific differences are controlled not only by sex hormones but also through a sex-chromosome-dependent mechanism. A new study in mice shows that cardiac sex-specific disparities appear at early stages of heart development, before gonad formation, and that X-linked genes act outside of the gonads in a dosage-dependent mechanism to regulate male–female cardiac differences.
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Influenza vaccination shortly after a myocardial infarction or in high-risk coronary heart disease reduces the risk of future cardiovascular events, according to findings from the IAMI trial.
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