Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels
Volume: 114, Issue: 22, Pages: 5647 - 5652
Published: May 15, 2017
Abstract
The spatial presentation of mechanical information is a key parameter for cell behavior. We have developed a method of polymerization control in which the differential diffusion distance of unreacted cross-linker and monomer into a prepolymerized hydrogel sink results in a tunable stiffness gradient at the cell-matrix interface. This simple, low-cost, robust method was used to produce polyacrylamide hydrogels with stiffness gradients of 0.5,...
Paper Details
Title
Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels
Published Date
May 15, 2017
Volume
114
Issue
22
Pages
5647 - 5652
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