Original paper
Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand
Abstract
The Smoothened receptor (SMO) belongs to the Class Frizzled of the G protein-coupled receptor (GPCR) superfamily, constituting a key component of the Hedgehog signalling pathway. Here we report the crystal structure of the multi-domain human SMO, bound and stabilized by a designed tool ligand TC114, using an X-ray free-electron laser source at 2.9 Å. The structure reveals a precise arrangement of three distinct domains: a seven-transmembrane...
Paper Details
Title
Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand
Published Date
May 17, 2017
Journal
Volume
8
Issue
1