Original paper

Genetic regulation of the RUNX transcription factor family has antitumor effects

Volume: 127, Issue: 7, Pages: 2815 - 2828
Published: May 22, 2017
Abstract
Runt-related transcription factor 1 (RUNX1) is generally considered to function as a tumor suppressor in the development of leukemia, but a growing body of evidence suggests that it has pro-oncogenic properties in acute myeloid leukemia (AML). Here we have demonstrated that the antileukemic effect mediated by RUNX1 depletion is highly dependent on a functional p53-mediated cell death pathway. Increased expression of other RUNX family members,...
Paper Details
Title
Genetic regulation of the RUNX transcription factor family has antitumor effects
Published Date
May 22, 2017
Volume
127
Issue
7
Pages
2815 - 2828
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