Structural insight into allosteric modulation of protease-activated receptor 2

Nature64.80
Volume: 545, Issue: 7652, Pages: 112 - 115
Published: Apr 26, 2017
Abstract
Crystal structures of protease-activated receptor 2 (PAR2) in complex with two different antagonist ligands and with a blocking antibody reveal binding sites that are distinct from those found on PAR1, offering new leads for structure-based drug design. Protease-activated receptors (PARs) are a family of G-protein-coupled receptors (GPCRs) with roles in diverse diseases, such as neuroinflammation and cancer, and are considered important target...
Paper Details
Title
Structural insight into allosteric modulation of protease-activated receptor 2
Published Date
Apr 26, 2017
Journal
Volume
545
Issue
7652
Pages
112 - 115
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