Original paper
Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
Abstract
Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases, such as osteoporosis, diabetes and obesity. Here we report the structure of a full-length class B receptor, the calcitonin receptor, in complex with peptide ligand and heterotrimeric Gαsβγ protein determined by Volta phase-plate single-particle cryo-electron microscopy. The peptide agonist engages the receptor by binding to an extended hydrophobic pocket...
Paper Details
Title
Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
Published Date
Apr 24, 2017
Journal
Volume
546
Issue
7656
Pages
118 - 123
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Notes
History