Development and validation of a predictive risk model for acute skin toxicity in patients undergoing breast radiotherapy

Background: Clinically significant side-effects from radiotherapy affect around a quarter of breast cancer patients and may have a considerable impact on outcomes from breast surgery. Breast surgeons are invariably influenced in their clinical decision-making by the potential impact of post-operative radiotherapy on breast cosmesis and quality of life. If patients at high risk of radiation toxicity could be identified pre-operatively, this could...