DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age
Abstract
Summary Age‐related bone loss in mice results from a decrease in bone formation and an increase in cortical bone resorption. The former is accounted by a decrease in the number of postmitotic osteoblasts which synthesize the bone matrix and is thought to be the consequence of age‐dependent changes in mesenchymal osteoblast progenitors. However, there are no specific markers for these progenitors, and conclusions rely on results from in vitro...
Paper Details
Title
Published Date
Apr 12, 2017
Journal
Volume
16
Issue
4
Pages
693 - 703
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