Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells

Volume: 74, Issue: 18, Pages: 3347 - 3362
Published: Apr 17, 2017
Abstract
Nicotinamide (NAM), a form of vitamin B3, plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. These non-redox enzymes include the sirtuin family proteins which deacetylate target proteins while cleaving NAD+ to yield NAM. Since the finding that NAM exerts feedback inhibition to the sirtuin reactions, NAM has been widely...
Paper Details
Title
Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells
Published Date
Apr 17, 2017
Volume
74
Issue
18
Pages
3347 - 3362
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