Cellular and Molecular Life Sciences
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#1Gabriela Caballero-Vidal (University of Paris)
#2Cédric Bouysset (CNRS: Centre national de la recherche scientifique)H-Index: 5
Last. Emmanuelle Jacquin-Joly (University of Paris)H-Index: 36
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The concept of reverse chemical ecology (exploitation of molecular knowledge for chemical ecology) has recently emerged in conservation biology and human health. Here, we extend this concept to crop protection. Targeting odorant receptors from a crop pest insect, the noctuid moth Spodoptera littoralis, we demonstrate that reverse chemical ecology has the potential to accelerate the discovery of novel crop pest insect attractants and repellents. Using machine learning, we first predicted novel na...
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#1Monika Pichla (UPR-RP: UPRRP College of Natural Sciences)H-Index: 2
#2Flore Sneyers (Katholieke Universiteit Leuven)H-Index: 4
Last. Martijn Kerkhofs (Katholieke Universiteit Leuven)H-Index: 10
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Membrane-contact sites are getting more and more credit for their indispensable role in maintenance of cell function and homeostasis. In the last decades, the ER-mitochondrial contact sites in particular received a lot of attention. While our knowledge of ER-mitochondrial contact sites increases steadily, the focus often lies on a static exploration of their functions. However, it is increasingly clear that these contact sites are very dynamic. In this review, we highlight the dynamic nature of ...
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#1Anne-Marie Galow (Leibniz Association)H-Index: 3
#2Sophie Kussauer (University of Rostock)H-Index: 1
Last. Andreas Hoeflich (Leibniz Association)H-Index: 45
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Single-cell RNA-sequencing (scRNA-seq) provides high-resolution insights into complex tissues. Cardiac tissue, however, poses a major challenge due to the delicate isolation process and the large size of mature cardiomyocytes. Regardless of the experimental technique, captured cells are often impaired and some capture sites may contain multiple or no cells at all. All this refers to "low quality" potentially leading to data misinterpretation. Common standard quality control parameters involve th...
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#1Nicole Rummel (UK: University of Kentucky)
#2Luksana Chaiswing (UK: University of Kentucky)H-Index: 20
Last. D. Allan Butterfield (UK: University of Kentucky)H-Index: 136
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Chemotherapy-induced cognitive impairment (CICI) has been observed in a large fraction of cancer survivors. Although many of the chemotherapeutic drugs do not cross the blood-brain barrier, following treatment, the structure and function of the brain are altered and cognitive dysfunction occurs in a significant number of cancer survivors. The means by which CICI occurs is becoming better understood, but there still remain unsolved questions of the mechanisms involved. The hypotheses to explain C...
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#1Tess A. V. Afanasyeva (Radboud University Nijmegen)
#2Julio C. Corral-Serrano (UCL Institute of Ophthalmology)H-Index: 1
Last. Rob W.J. Collin (Radboud University Nijmegen)H-Index: 41
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Inherited retinal diseases (IRDs) cause progressive loss of light-sensitive photoreceptors in the eye and can lead to blindness. Gene-based therapies for IRDs have shown remarkable progress in the past decade, but the vast majority of forms remain untreatable. In the era of personalised medicine, induced pluripotent stem cells (iPSCs) emerge as a valuable system for cell replacement and to model IRD because they retain the specific patient genome and can differentiate into any adult cell type. T...
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#1Helen Ray-Jones (Imperial College London)
#2Mikhail Spivakov (Imperial College London)H-Index: 29
Transcriptional enhancers play a key role in the initiation and maintenance of gene expression programmes, particularly in metazoa. How these elements control their target genes in the right place and time is one of the most pertinent questions in functional genomics, with wide implications for most areas of biology. Here, we synthesise classic and recent evidence on the regulatory logic of enhancers, including the principles of enhancer organisation, factors that facilitate and delimit enhancer...
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#1Andrey S. Marchev (BAS: Bulgarian Academy of Sciences)H-Index: 12
#2Liliya V. Vasileva (BAS: Bulgarian Academy of Sciences)
Last. Milen I. Georgiev (BAS: Bulgarian Academy of Sciences)H-Index: 28
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During the past decade metabolomics has emerged as one of the fastest developing branches of "-omics" technologies. Metabolomics involves documentation, identification, and quantification of metabolites through modern analytical platforms in various biological systems. Advanced analytical tools, such as gas chromatography-mass spectrometry (GC/MS), liquid chromatography-mass spectroscopy (LC/MS), and non-destructive nuclear magnetic resonance (NMR) spectroscopy, have facilitated metabolite profi...
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#1Donatella Farini (University of Rome Tor Vergata)H-Index: 22
#2Daniela MarazzitiH-Index: 12
Last. Claudio SetteH-Index: 59
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In the past two decades, mounting evidence has modified the classical view of the cerebellum as a brain region specifically involved in the modulation of motor functions. Indeed, clinical studies and engineered mouse models have highlighted cerebellar circuits implicated in cognitive functions and behavior. Furthermore, it is now clear that insults occurring in specific time windows of cerebellar development can affect cognitive performance later in life and are associated with neurological synd...
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#1Emanuela D'Acunto (Sapienza University of Rome)H-Index: 2
#2Annamaria Fra (University of Brescia)H-Index: 8
Last. Elena Miranda (Sapienza University of Rome)H-Index: 29
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Neuroserpin is a serine protease inhibitor identified in a search for proteins implicated in neuronal axon growth and synapse formation. Since its discovery over 30 years ago, it has been the focus of active research. Many efforts have concentrated in elucidating its neuroprotective role in brain ischemic lesions, the structural bases of neuroserpin conformational change and the effects of neuroserpin polymers that underlie the neurodegenerative disease FENIB (familial encephalopathy with neuros...
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#1Eliza Mari Kwesi-Maliepaard (NKI-AVL: Netherlands Cancer Institute)H-Index: 3
#2Heinz Jacobs (NKI-AVL: Netherlands Cancer Institute)H-Index: 33
Last. Fred W. van Leeuwen (NKI-AVL: Netherlands Cancer Institute)H-Index: 58
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Conventional CD8+ memory T cells develop upon stimulation with foreign antigen and provide increased protection upon re-challenge. Over the past two decades, new subsets of CD8+ T cells have been identified that acquire memory features independently of antigen exposure. These antigen-inexperienced memory T cells (TAIM) are described under several names including innate memory, virtual memory, and memory phenotype. TAIM cells exhibit characteristics of conventional or true memory cells, including...
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