Dual stimuli-responsive poly(succinyloxyethylmethacrylate-b-N-isopropylacrylamide) block copolymers as nanocarriers and respective application in doxorubicin delivery

Stimuli-responsive nanostructures were developed as anticancer drug delivery carriers. To this end, poly(2-hydroxyethylmethacrylate)-b-(N-isopropylacrylamide) (poly(HEMA-b-NIPAAm)) diblock copolymers were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization with two ratios remarked with (1) and (2). Based on gel permeation chromatography, the molecular weights of synthesized diblock copolymers were 17802 (1) and...