Original paper

Gene products promoting remyelination are up-regulated in a cell therapy product manufactured from banked human cord blood

Volume: 19, Issue: 6, Pages: 771 - 782
Published: Jun 1, 2017
Abstract
DUOC-01, a cell product being developed to treat demyelinating conditions, is composed of macrophages that arise from CD14+ monocytes in the mononuclear cell (MNC) population of banked cord blood (CB). This article demonstrates that expression of multiple gene products that promote remyelination is rapidly up-regulated during manufacturing of DUOC-01 from either MNC or purified CB CD14+ monocytes.Cell cultures were initiated with MNC or with...
Paper Details
Title
Gene products promoting remyelination are up-regulated in a cell therapy product manufactured from banked human cord blood
Published Date
Jun 1, 2017
Volume
19
Issue
6
Pages
771 - 782
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