IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population
Abstract
Patients who survive sepsis can develop long-term immune dysfunction, with expansion of the regulatory T (Treg) cell population. However, how Treg cells proliferate in these patients is not clear. Here we show that IL-33 has a major function in the induction of this immunosuppression. Mice deficient in ST2 (IL-33R) develop attenuated immunosuppression in cases that survive sepsis, whereas treatment of naive wild-type mice with IL-33 induces...
Paper Details
Title
IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population
Published Date
Apr 4, 2017
Journal
Volume
8
Issue
1
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