Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF–IRF4 transcription factor complex

Murphy and colleagues show that the transcription-factor complex BATF-IRF4, which recognizes AICE motifs within gene enhancers, is sensitive to TCR signaling strength and identify distinct gene targets that respond to graded doses of TCR stimulation. Variable strengths of signaling via the T cell antigen receptor (TCR) can produce divergent outcomes, but the mechanism of this remains obscure. The abundance of the transcription factor IRF4...