Original paper
Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD
Abstract
To examine whether a polygenic risk score (PRS) derived from APOE4, CLU, and ABCA7 is associated with CSF biomarkers of Alzheimer disease (AD) pathology and whether higher cardiorespiratory fitness (CRF) modifies the association between the PRS and CSF biomarkers.Ninety-five individuals from the Wisconsin Registry for Alzheimer's Prevention were included in these cross-sectional analyses. They were genotyped for APOE4, CLU, and ABCA7, from which...
Paper Details
Title
Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD
Published Date
Apr 25, 2017
Journal
Volume
88
Issue
17
Pages
1650 - 1658
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Notes
History