Conformational dynamics and role of the acidic pocket in ASIC pH-dependent gating

Volume: 114, Issue: 14, Pages: 3768 - 3773
Published: Mar 20, 2017
Abstract
Significance Many physiological processes are regulated by pH. The acid-sensing ion channels (ASICs) are neuronal pH sensors involved in learning, fear behavior, neurodegeneration after ischemic stroke, and pain sensation. The mechanism by which acidic pH activates ASICs is still poorly understood. We show here that the “acidic pocket,” the binding site of several toxins, is not essential for channel function but has, rather, a modulatory role....
Paper Details
Title
Conformational dynamics and role of the acidic pocket in ASIC pH-dependent gating
Published Date
Mar 20, 2017
Volume
114
Issue
14
Pages
3768 - 3773
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.