Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer
Abstract
Most common breast cancer susceptibility variants have been identified through genome-wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease. We conducted a GWAS using 21,468 ER-negative cases and 100,594 controls combined with 18,908 BRCA1 mutation carriers (9,414 with breast cancer), all of European origin. We identified independent associations at P < 5 × 10-8 with ten variants at nine new loci. At P < 0.05,...
Paper Details
Title
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer
Published Date
Oct 23, 2017
Journal
Volume
49
Issue
12
Pages
1767 - 1778
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