Calcium‐dependent Nedd4‐2 upregulation mediates degradation of the cardiac sodium channel Nav1.5: implications for heart failure
Abstract
Aim Reductions in voltage‐gated sodium channel (Nav1.5) function/expression provide a slowed‐conduction substrate for cardiac arrhythmias. Nedd4‐2, which is activated by calcium, post‐translationally modulates Nav1.5. We aim to investigate whether elevated intracellular calcium ([Ca 2+ ] i ) reduces Nav1.5 through Nedd4‐2 and its role in heart failure ( HF ). Methods Using a combination of biochemical, electrophysiological, cellular and in vivo...
Paper Details
Title
Calcium‐dependent Nedd4‐2 upregulation mediates degradation of the cardiac sodium channel Nav1.5: implications for heart failure
Published Date
Mar 10, 2017
Journal
Volume
221
Issue
1
Pages
44 - 58
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