Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel

Intracellular trafficking of the voltage-gated cardiac Na+ channel Nav1.5 is regulated by lysine deacetylation mediated by Sirt1, thereby affecting sodium current and cardiac electrical activity. The voltage-gated cardiac Na+ channel (Nav1.5), encoded by the SCN5A gene, conducts the inward depolarizing cardiac Na+ current (INa) and is vital for normal cardiac electrical activity. Inherited loss-of-function mutations in SCN5A lead to defects in...