Original paper
Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone
Abstract
: Drug delivery carriers can maintain effective therapeutic concentrations in the eye. To this end, we developed lipid nanoparticles (L/NPs) in which the surface was modified with positively charged chitosan, which engaged in hydrogen bonding with the phospholipid membrane. We evaluated in vitro corneal permeability and release characteristics, ocular irritation, and drug dynamics of modified and unmodified L/NPs in aqueous humor. The size of...
Paper Details
Title
Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone
Published Date
Feb 1, 2017
Volume
Volume 12
Pages
1329 - 1339