Review paper
Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer
Abstract
Malignant cells utilize diverse strategies that enable them to thrive under adverse conditions while simultaneously inhibiting the development of anti-tumor immune responses. Hostile microenvironmental conditions within tumor masses, such as nutrient deprivation, oxygen limitation, high metabolic demand, and oxidative stress, disturb the protein-folding capacity of the endoplasmic reticulum (ER), thereby provoking a cellular state of "ER...
Paper Details
Title
Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer
Published Date
Feb 1, 2017
Journal
Volume
168
Issue
4
Pages
692 - 706
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Notes
History