Radiation with or without Antiandrogen Therapy in Recurrent Prostate Cancer

Published on Feb 1, 2017in The New England Journal of Medicine74.699
路 DOI :10.1056/NEJMOA1607529
William U. Shipley100
Estimated H-index: 100
(Harvard University),
W. Seiferheld18
Estimated H-index: 18
+ 19 AuthorsHoward M. Sandler96
Estimated H-index: 96
BackgroundSalvage radiation therapy is often necessary in men who have undergone radical prostatectomy and have evidence of prostate-cancer recurrence signaled by a persistently or recurrently elevated prostate-specific antigen (PSA) level. Whether antiandrogen therapy with radiation therapy will further improve cancer control and prolong overall survival is unknown. MethodsIn a double-blind, placebo-controlled trial conducted from 1998 through 2003, we assigned 760 eligible patients who had undergone prostatectomy with a lymphadenectomy and had disease, as assessed on pathological testing, with a tumor stage of T2 (confined to the prostate but with a positive surgical margin) or T3 (with histologic extension beyond the prostatic capsule), no nodal involvement, and a detectable PSA level of 0.2 to 4.0 ng per milliliter to undergo radiation therapy and receive either antiandrogen therapy (24 months of bicalutamide at a dose of 150 mg daily) or daily placebo tablets during and after radiation therapy. The p...
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