Redox‐Activatable ATP‐Depleting Micelles with Dual Modulation Characteristics for Multidrug‐Resistant Cancer Therapy

A fast adenosine triphosphate (ATP)‐depleting micellar system that is activated by intracellular redox for the codelivery of anticancer drug paclitaxel (PTX) and small interference RNA (siRNA) targeting polo‐like kinase1 (PLK1) is developed to address the key challenges of multidrug‐resistant (MDR) cancer therapy. The ATP‐depleting micelle is self‐assembled from a redox‐responsive amphiphilic polymer (termed as bPEG‐SS‐P123‐PEI (PSPP)) that is...