Structural Insight into the Molecular Mechanism of TRPA1 Inhibition and Activation

Pain, while serving the beneficial function of provoking our attention to dangerous situations, is an unpleasant sensory and emotional experience. Transient Receptor Potential Ankyrin 1 (TRPA1) is a member of the transient receptor potential (TRP) cation channel family and is localized in nerve fibers called “nociceptors” where it plays a key role in the transduction of chemical, inflammatory and neuropathic pain signals from the periphery to...