Original paper
Soluplus micelles for improving the oral bioavailability of scopoletin and their hypouricemic effect in vivo
Abstract
Scopoletin is an active coumarin possessing a variety of pharmacological activities, including anti-hyperuricemic effect, but with poor solubility. To improve its oral bioavailability, we attempted to encapsulate scopoletin into Soluplus micelles (Soluplus-based scopoletin micelles, Sco-Ms) and evaluated the hypouricemic action of Sco-Ms. Sco-Ms were prepared using a thin-film hydration method. Sco-Ms displayed near spherical shapes with an...
Paper Details
Title
Soluplus micelles for improving the oral bioavailability of scopoletin and their hypouricemic effect in vivo
Published Date
Jan 23, 2017
Journal
Volume
38
Issue
3
Pages
424 - 433
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Notes
History