Zhirong Zhang
Sichuan University
CytotoxicityPharmacokineticsBiophysicsDrug carrierMolecular biologyNanoparticleLiposomeChemistryMaterials scienceIn vitroIn vivoPaclitaxelBiodistributionDrug deliveryDoxorubicinChromatographyCancer researchBiochemistryMedicineBiologyImmune systemPharmacology
430Publications
63H-index
10.4kCitations
Publications 442
Newest
#1Mou Wang (Sichuan University)H-Index: 2
#2Shuying Wang (Sichuan University)
Last. Yao Fu (Sichuan University)H-Index: 27
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Postsurgical recurrence of breast cancer is closely related to the inflammatory tumor microenvironment evoked by surgical wounds. Toll-like receptor 4 (TLR4) signaling contributes to NF-κB activation thus secreting various inflammatory cytokines. Herein, we developed an in situ photo-crosslinked hydrogel (D/T gel) concurrently loaded with doxorubicin (DOX) and a TLR4 antagonist, resatorvid (TAK-242). Its therapeutic effect against breast cancer postsurgical relapse was accomplished through remod...
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#1Lang Deng (Sichuan University)H-Index: 3
#2Hanming Zhang (Sichuan University)
Last. Ling Zhang (Sichuan University)H-Index: 9
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Pancreatic carcinoma elevates quickly and thus has a high mortality rate. Therefore, early treatment is essential for treating pancreatic carcinoma. KRAS is the most frequently identified and one of the earliest mutations in pancreatic tumorigenesis. Thus, the KRAS-mutant cell is an ideal target for the treatment of pancreatic carcinoma, especially at the early stage. KRAS mutation increases macropinocytosis in pancreatic cancer cells, enhancing the internalization of exosomes. Because acquiring...
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#1Yu Fu (SWU: Southwest University)
#1Yu Fu (SWU: Southwest University)H-Index: 7
Last. Ling Zhang (Sichuan University)H-Index: 9
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Abstract null null Current clinical agents for autoimmunity disorders treatment often cause substantial adverse effects and safety concerns, owing to non-specific immune modulation. Due to the prominent contribution of effector T cells in pathogenesis of rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), and preferential location of co-stimulatory receptor-ligand pair OX40-OX40L at the inflamed sites, selectively targeting autoaggressive T cells by blockade OX40-OX40L, might represe...
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#1Kebai Ren (Sichuan University)H-Index: 4
#2Qiu Yue (University of Electronic Science and Technology of China)
Last. Zhirong Zhang (Sichuan University)H-Index: 63
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Surgery combined with postoperative treatment is a widely accepted therapeutic strategy against breast cancer. Macrophage-based carriers have been proved to be an effective postoperative drug delivery system due to their inflammatory tendency. However, the slow and incomplete release of the cargo and the postoperative inflammation remain to be solved. Here, we described a macrophage-mediated photothermal therapy combined with anti-inflammatory strategy to inhibit breast cancer postoperative rela...
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#1Zhengze Lu (Sichuan University)H-Index: 7
#2Yang Long (Sichuan University)H-Index: 9
Last. Qin He (Sichuan University)H-Index: 44
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Abstract Pancreatic ductal adenocarcinoma is one of the most lethal malignant tumors, its drug resistance, immunosuppression and metastasis makes the traditional chemotherapy and immunotherapy inefficient. Here we confirmed a 3-aminophenylboronic acid-modified low molecular weight heparin-D-α-tocopheryl succinate micellar nanoparticle (PBA-LMWH-TOS NP, PLT NP) could inhibit orthotopic pancreatic tumor and its spontaneous metastases. The small particle size and high affinity of PBA to sialic acid...
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#1Chunyu Xia (Sichuan University)H-Index: 7
#2Man Li (Sichuan University)H-Index: 18
Last. Qin He (Sichuan University)H-Index: 44
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Myeloid-derived suppressor cells (MDSCs) are the chief accomplices for assisting tumor's survival and suppressing anti-tumor immunity, which can be recruited by tumor-derived cytokines, such as granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF). The plentiful lactate dehydrogenase A (LDHA) in glycolysis is usually accompanied by abundant tumor-derived G-CSF and GM-CSF, further promoting MDSCs recruitment and immunosuppression. Herein, with...
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#1Qinglin Sheng (Sichuan University)H-Index: 2
#2Ting Li (Sichuan University)
Last. Qin He (Sichuan University)H-Index: 44
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Facing the barriers in each step of the in vivo delivery cascade, the low drug delivery efficiency remains problematic in tumor therapy. Although recently the nanofibril drug delivery systems have shown improved circulation and accumulation compared with nanoparticles, the poor deep penetration and cellular internalization hinder their application, especially for pancreatic cancer with dense stroma. To comprehensively address the hurdles in the delivery cascade, a matrix metalloproteinase 2 (MMP...
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#1Yi Liang (Sichuan University)H-Index: 4
#2Zhirong Zhang (Sichuan University)H-Index: 63
The transformersome is a new kind of lipoid drug delivery carrier. It has a number of excellent properties, including deformability, pressure permeability, and amphiphilicity. It has been widely used in the field of percutaneous and oral administration of medication. However, due to factors concerning its formulation, the stability and effectiveness of intravenous injection and other systemic routes of administration of transfersomes should be carefully examined. As an alternative, the formulati...
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#1Bangqing Wu (Sichuan University)
#2Yingju He (Sichuan University)H-Index: 2
Last. Li Deng (Sichuan University)H-Index: 8
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Objective To prepare encapsulated clopidogrel bisulfate (CLP) liposomes so as to deal with the poor water solubility of CLP, and to provide the experimental basis for the development of CLP formulations for intravascular injection. Methods CLP-loaded liposomes were prepared using thin film hydration/sonication method and pH gradient active drug loading technology. Then, the morphology, particle size, encapsulation efficiency, drug loading capacity, Zeta potentials and in vitro release behavior w...
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Pharmaceutical sciences and pharmaceutical materials are a discipline that studies drug dosage forms, formulation technology, and drug release patterns and mechanisms. This article briefly discusses the fundamental research and application of pharmaceutical sciences/pharmaceutical materials, summarizes the hot research topics of pharmaceutical sciences/pharmaceutical materials in China over the past 20 years, and analyzes the international status, achievements, and strengths and weaknesses of re...
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