Dapagliflozin in patients with type 1 diabetes: Apost hoc analysis of the effect of insulin dose adjustments on 24-hour continuously monitored mean glucose and fasting β-hydroxybutyrate levels in a phase IIa pilot study

Aims To investigate the effects of total daily insulin dose ( TDD ) reductions on 24‐hour continuously monitored mean glucose and fasting β‐hydroxybutyrate (a marker for diabetic ketosis/ketoacidosis [ DKA ]) levels, using patient‐level data from a 14‐day, pilot study of dapagliflozin in type 1 diabetes ( T1DM ). Methods A post hoc exploratory correlation analysis was performed to determine the relationship between change in TDD and (1) 24‐hour...