Review paper
EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression
Abstract
Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well as with generation and maintenance of cancer stem cells. In this way, EMT contributes to tumor invasion, heterogeneity and chemoresistance. Morphological and functional changes involved in these processes require robust reprogramming of gene expression, which is only partially accomplished at the transcriptional level. Alternative splicing is another...
Paper Details
Title
EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression
Published Date
Jan 30, 2017
Journal
Volume
16
Issue
1
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