Original paper

The Rodent Liver Undergoes Weaning-Induced Involution and Supports Breast Cancer Metastasis

Volume: 7, Issue: 2, Pages: 177 - 187
Published: Feb 1, 2017
Abstract
Patients with postpartum breast cancer are at increased risk for metastasis compared with age-matched nulliparous or pregnant patients. Here, we address whether circulating tumor cells have a metastatic advantage in the postpartum host and find the postlactation rodent liver preferentially supports metastasis. Upon weaning, we observed liver weight loss, hepatocyte apoptosis, extracellular matrix remodeling including deposition of collagen and...
Paper Details
Title
The Rodent Liver Undergoes Weaning-Induced Involution and Supports Breast Cancer Metastasis
Published Date
Feb 1, 2017
Volume
7
Issue
2
Pages
177 - 187
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